Abstract # 139:

Scheduled for Friday, August 19, 2005 03:25 PM-04:00 PM: Session 12 (Crystal Ballroom) Oral Presentation


GENOME SEQUENCE OF THE RHESUS MACAQUE (MACACA MULATTA)

G. Weinstock, R. Gibbs and .. the Rhesus Macaque Genome Sequencing Consortium
Baylor College of Medicine, Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA
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     The production of a draft genome sequence of the rhesus macaque is being performed by the Rhesus Macaque Genome Sequencing Consortium (RMGSC). The RMGSC is led by the Baylor College of Medicine Human Genome Sequencing Center, and in collaboration with the Genome Sequencing Center at Washington University, St. Louis, and the J. Craig Venter Institute Joint Technology Center. In addition, a BAC-based physical map is being constructed by the British Columbia Genome Sciences Centre, Vancouver. The goals of the project are to produce a seven-fold whole-genome shotgun assembly, using small insert plasmids as well as large insert clone ends from BACs, Fosmids, and 50kb linking clones. There will be finishing and BAC sequencing components of the project to investigate interesting regions for human diseases and to highlight primate evolution. The rhesus macaque is an Old World monkey. This primate model organism is important for study of human disease due to their genetic, physiologic and metabolic similarity to humans. Rhesus monkeys are used for essential research in neuroscience, behavioral biology, reproductive physiology, endocrinology, cardiovascular studies, pharmacology and other areas. Supported by the National Human Genome Research Institute