Abstract # 13133 Event # 45:

Scheduled for Thursday, August 9, 2018 03:45 PM-04:15 PM: (Chula Vista ) Oral Presentation


CURRENT STATUS AND NEAR-TERM PROSPECTS FOR PRIMATE GENOMICS

J. Rogers
Baylor College of Medicine, Human Genome Sequencing Center, One Baylor Plaza, Houston, Texas 77030, USA
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     The rapid development of genomic technologies (DNA and RNA sequencing, epigenetics and others) have opened a wide range of new research opportunities related to nonhuman primates.  The reduced cost and greater accessibility of genomic data and analyses have created many exciting new avenues for research. Specifically, whole genome sequencing using Illumina short-read and/or Pacific Biosciences long-read methods has produced reference genome sequences for 22 species, including hominoids (e.g. Pan troglodytes, Gorilla gorilla), Old World monkeys (e.g Macaca mulatta, Papio anubis, Chlorocebus aethiops), New World monkeys (e.g. Callithrix jacchus, Aotus nancymaae) and strepsirrhine primates. Whole genome sequencing of multiple individuals from 9 different catarrhine species using Illumina short-read methods shows that many (probably most) species exhibit higher levels of within-species genetic variation than do humans. The data suggest this includes substantial amounts of functionally significant protein-coding variation; our laboratory has identified more than 300,000 different missense variants in rhesus macaques.  Evidence is now accumulating for other types of genomic variation beyond simple nucleotide substitutions, such as copy number variation and individual differences in DNA methylation. This presentation will summarize the current state of primate genomics, critically review some recent empirical studies and describe one person's perspective on the potential to incorporate genetic and genomic methods into a variety of primate research programs.