Abstract # 13165 Poster # 96:

Scheduled for Thursday, August 9, 2018 06:00 PM-08:00 PM: (Chula Vista ) Poster Presentation


USE OF A NOVEL IMMUNOTHERAPEUTIC APPROACH TO IMPROVE LEARNING AND MEMORY IN OLDER FEMALE SQUIRREL MONKEYS

 

L. E. Williams and H. Scholtzova
NYU School of Medicine, Michale E. Keeling Center for Comparative Medicine, Department of Veterinary Sciences, Bastrop, TX 78602, USA
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Studies in mice have shown that the stimulation of innate immunity can ameliorate Alzheimer’s disease (AD) related pathology, including cerebral amyloid angiopathy (CAA). We postulated that stimulation of the innate immune system with class B CpG ODN, via the Toll-like receptor 9 (TLR9), moderate AD pathology without associated toxicity. We have begun to test this hypothesis using squirrel monkeys (Saimiri boliviensis) which are a well-characterized non-human primate model of sporadic CAA. An Inhibitory Control Task was used to assess changes in learning and memory. A food reward was presented inside a clear container with an opening on one side. Each test consisted of four five-trial sessions. The container opening was placed on either the left or right hand side based on a predetermined, randomized schedule. Between session two and three the container was rotated 180o for the remainder of the test. Tests were repeated once daily for 14 days, recording the number incorrect responses during each trial. A repeated measures ANOVA (α=0.05) showed that non-treated control group of older females performed significantly worse than a CpG ODN- treated older female group and a non-treated group of young females. Our non-treated animals failed to inhibit the initial learned response after a spatial reversal that required learning the reversed box-opening orientation. This suggests that our novel immunotherapeutic approach will be effective in improving spatial memory.