Abstract # 13168 Poster # 98:

Scheduled for Thursday, August 9, 2018 06:00 PM-08:00 PM: (Chula Vista ) Poster Presentation


NEONATAL PREDICTORS OF ADOLESCENT ALCOHOL INTAKE: A RHESUS MONKEY (MACACA MULATTA) MODEL

E. K. Wood1, S. J. Suomi2 and J. D. Higley1
1Brigham Young University, Psychology Department, Provo, Utah 84602, USA, 2Section of Comparative Ethology, Eunice Shriver Kennedy National Institute of Child Health and Human Development, National Institutes of Health
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     Research regarding teenage alcohol abuse focuses on identifying underlying predictors in alcohol-abusing individuals, with studies suggesting distinct temperament-related correlates with alcoholism typologies. As temperament is biologically-based, identified early in life, and is stable across time, we hypothesized that variation in adolescent alcohol use could be predicted from an assessment of infant temperamental traits. To test this, at 14 days of life, N=145 laboratory-living rhesus macaque (Macaca mulatta) infants, reared in a neonatal nursery (n=82) or in a control condition (n=63), were assessed using a standardized testing battery evaluating visual orienting, temperament, and motor maturity. As adolescents (3 years of life), subjects were allowed unfettered access to a sweetened-alcohol solution for 1 hour/day, 4 days/week, over 5-7 weeks. Subjects drank while housed alone (n=70) or socially in their home cage (n=55). Controlling for sex, rearing, and drinking conditions, analyses showed that alcohol intake was predicted by neonatal orienting ability (?= -.24; p< .05) and motor maturity (?= -.58; p< .01). Neonates with the lowest orientation and motor maturity scores consumed the most alcohol as adolescents, independent of sex, rearing, or drinking condition. These findings suggest that neonatal temperament and its biological underpinnings may provide the basis of risk for adolescent alcohol consumption.