Abstract # 13190 Event # 149:

Scheduled for Friday, August 10, 2018 03:15 PM-03:30 PM: (Chula Vista ) Oral Presentation


SOCIAL STABILITY INFLUENCES THE ASSOCIATION BETWEEN ADRENAL RESPONSIVENESS AND HAIR CORTISOL CONCENTRATIONS IN RHESUS MACAQUES (MACACA MULATTA)

J. J. Vandeleest1, J. P. Capitanio1, A. Hamel2, J. Meyer2, M. Novak2, S. P. Mendoza1 and B. McCowan1
1California National Primate Research Center, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA, 2University of Massachusetts, Amherst
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     Hair cortisol concentrations (HCC) are increasingly used as a biomarker of chronic stress but details regarding how HCC relate to the dynamic regulation of the HPA axis are unknown. The current study explores 1) how regulation of the HPA axis in infancy relates to HCC in infancy 2) whether this relationship persists into adulthood, and 3) the impact of social instability. Subjects were rhesus monkeys housed in large social groups at the CNPRC that had participated in a BioBehavioral Assessment (BBA) at 3-4 months of age. At BBA, four plasma cortisol samples assessed HPA responses to 1) social separation and relocation, 2) sustained challenge, 3) dexamethasone and 4) ACTH administration. Hair samples were collected at the end of the BBA for a total of 56 infants, 25 from stable and 31 from unstable social groups. Adult hair samples were obtained at three timepoints from 145 adults, 108 from stable and 37 from unstable social groups. Generalized linear models were used with alpha<0.05. For infants and adults living in stable social groups, HCC were associated with the adrenal response to ACTH from BBA. In unstable social groups, adult hair cortisol levels were higher than in stable social groups but no consistent relationships between HCC and HPA axis regulation was found. These results suggest that the HPA axis mechanisms driving HCC may differ depending on social context.