Abstract # 13201 Event # 137:

Scheduled for Friday, August 10, 2018 02:00 PM-04:00 PM: (Chula Vista ) Oral Presentation


SEROTONIN RECEPTOR 1A (5-HTR1A) VARIATION IS ASSOCIATED WITH ANXIETY AND AGONISTIC BEHAVIOR IN CAPTIVE CHIMPANZEES

N. Staes1, C. C. Sherwood1, H. Freeman2, S. F. Brosnan2,3,4, W. D. Hopkins4,5 and B. J. Bradley1
1The George Washington University, CASHP, 800 22nd ST NW, Washington, DC 20052, USA, 2Michael E Keeling Center for Comparitive Medicine and Research, University of Texas, 3Department of Psychology, Georgia State University, 4Neuroscience Institute and Language Research Center, Georgia State University, 5Ape Cognition and Conservation Initiative
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     Personality is partially controlled by genetic mechanisms in primates. Here we investigated the association between personality in chimpanzees (Pan troglodytes) with variation in the gene coding for 5-hydroxytryptamine receptor 1A (5-HTR1A). Personality was measured using two approaches: a personality psychology approach (rating: MD Anderson N=137, Yerkes N=77) and a behavioral ecology approach (coding: MD Anderson N=59). 5-HTR1A is a receptor that binds to serotonin, a neurotransmitter important for regulating anxiety, impulsivity and aggression, as documented in a variety of mammals. In chimpanzees, a C/A SNP is present in exon 1, changing a proline to a glutamine in the amino acid sequence (Pro248Gln). Genotyping was performed using high-resolution melt analysis and genotype frequencies were in Hardy Weinberg equilibrium (X2 = 0.20, df = 1, p = 0.656). The derived allele was present at higher frequency (0.67) in the population and associated with a reduction in anxiety (F(2,209) = 3.540, p = 0.031) and male displaying behavior (X2 (2) = 18.957, p = <0.001). These results are the first evidence that the 5-HTR1A gene potentially plays a role in regulating behavior in chimpanzees.