Abstract # 13203 Event # 150:

Scheduled for Friday, August 10, 2018 03:30 PM-03:45 PM: (Chula Vista ) Oral Presentation


MARMOSET GUT MICROBIOME AND AGING

C. N. Ross1,2 and K. R. Reveles2,3
1Texas A&M University San Antonio, Department of Science and Mathematics, One University Way, San Antonio, TX 78224, USA, 2University of Texas Health San Antonio, 3University of Texas Austin
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     The trillions of microbial cells living commensally within the human body are now being recognized as significant causes of shifts in human health and disease onset. Advances in genomic sequencing techniques have recently made it possible to closely define and evaluate the microbiome and metagenome. While differences in microbial diversity are often due to variance in the diet and environmental factors, there are general trends in the microbiome toward more proteolytic bacteria and fewer saccharolytic bacteria in aging people. The ability to transplant microbiome communities from a healthy phenotype to an unhealthy phenotype has been demonstrated in rodent studies of obesity, thus providing a potential new mechanism for intervening in disease states. In order to investigate whether microbiome transplantation is a viable option for protecting healthy aging or reversing aging affects, it is necessary to evaluate the intervention in an animal model. Fecal samples from 10 young and 10 old marmosets (Callithrix jacchus) were evaluated, young animals had a significantly higher Shannon’s index of diversity (3.46) than old marmosets (3.15), and they also differed significantly in their Beta diversity (p=0.019). Young animals with significant variance in diversity were selected as donors for fecal microbiome transplant to animals with reduced diversity. If microbiome diversity can be significantly altered via transplant it is possible that this could be a successful therapeutic for treating age related decline.