Abstract # 13214 Event # 48:

Scheduled for Thursday, August 9, 2018 02:45 PM-03:00 PM: (Regency East 1 ) Oral Presentation


LONG TERM EFFECTS OF CHRONIC INTRANASAL OXYTOCIN ON MALE MATE-GUARDING, PARTNER PREFERENCE AND SEPARATION RESPONSE

R. A. Del Razo1,2, M. Floch3 and K. L. Bales1,2
1University of California Davis, Davis, CA 95616, USA, 2California National Primate Research Center, 3Agrocampus Ouest, Rennes, France
line
     In the last decade, efforts have focused on determining the effects of intranasal oxytocin (IN-OT) and its potential as a treatment for disorders involving social dysfunction. However, not much is known about the chronic and long-term effects. Titi monkeys (Callicebus cupreus) form pair bonds, characterized by partner preference, mate guarding and distress upon separation. For this study, juvenile titi monkeys received a daily dose of IN-OT (0.8 IU/kg or saline) from 12 to 18 months of age and were paired with an unfamiliar animal at 30 months of age. At 1 week and 4 months, post-pairing subjects were tested in a partner preference test and mirror test and at 5 months post-pairing on a separation test. Titi monkeys do not recognize themselves in the mirror and respond to their reflection with mate guarding behaviors. The non-reflective back side of the mirror served as control. Results showed that OT males at 1 week spent more time in contact with their partner when presented with the reflective side compared to the back side of the mirror (p = 0.03). Preliminary results showed that OT males also spent more time in proximity to their partner at 1 week (p=0.03) and 4 months during a preference test (p= .01), males’ vocalizations did not differ during the separation. Funded by HD071998, P51 OD011107, and the Good Nature Institute.