Abstract # 13234 Poster # 70:

Scheduled for Thursday, August 9, 2018 06:00 PM-08:00 PM: (Chula Vista ) Poster Presentation


J. R. Makar, N. C. Rice and T. M. Myers
United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010, USA
     African green monkeys (AGMs; Chlorocebus aethiops sabaeus) may serve as an alternative laboratory primate model to commonly used macaques species. However, questions remain as to the ideal behavioral training parameters and whether differences in response acquisition exist as a function of sex and/or species. The present study investigated this by analyzing acquisition of an autoshaped touchscreen response of cynomolgus macaques (Macaca fascicularis) and AGMs. In the procedure, a neutral stimulus was paired with food pellet deliveries. Touching the stimulus was not required, but repeated pairings engendered responding in the majority of subjects. Post-hoc analyses were conducted to address whether response acquisition differed as a function of sex, species, stimulus movement, or their combination. Cynomolgus males (n=8) acquired the response faster with a moving stimulus, whereas cynomolgus females (n=8) acquired the response faster with a stationary stimulus, F(6,66) = 4.12, p = 0.001. In AGMs, the males (11/13; 85%) acquired the response more reliably with a stationary stimulus and the females (n=6) acquired the response equally well across conditions, F(4,16) = 0.49, p = .75. These results suggest that acquisition under conditions of stimulus movement may be differentially affected by sex and the species under study. AGMs do acquire responding but additional experiments will help determine how sex and species interact with behavioral phenomena historically discovered and elaborated almost exclusively using males and macaques.