Abstract # 13281 Event # 138:

Scheduled for Friday, August 23, 2019 02:45 PM-03:00 PM: (Room 326) Oral Presentation


STANDARD GROWTH AND DIARRHEA-ASSOCIATED GROWTH FALTERING OF OUTDOOR LAB-HOUSED INFANT RHESUS MACAQUES (MACACA MULATTA)

A. J. Haertel
Oregon National Primate Research Center, 505 NW 185th Ave, BEAVERTON, Oregon 97006, USA
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     Reference growth studies of lab-housed rhesus macaque infants have not accounted for diarrhea and the potential for growth faltering related to diarrhea. We hypothesized outdoor lab-housed rhesus macaque infants with a clinical history of diarrhea would have lower growth than otherwise healthy infants and using the lower 3rd percentile of healthy infant growth would be a cut-off criterion to screen for diarrhea-associated growth faltering. Using a retrospective cohort of 6495 infant weight records in a multiple linear regression, daily weight gain through the first year of life was determined by sex, housing type, and health status. Significant diarrhea-associated growth deficits were found for both sexes in both outdoor housing types (corral females: -0.9 g/day, F-statistic: F(1,6494)=56.37, P<0.0001; corral males -0.4 g/day, F-statistic: F(1,6494)=26.24, P<0.0001; shelter females: -1.4 g/day; F-statistic: F(1,6494)=324.31, P<0.0001; shelter males: -1.4 g/day; F-statistic: F(1,6494)=267.48, P<0.0001). Odds of growth faltering of infants, defined as those falling below the 3rd percentile of healthy growth, were at least 8.9 higher given a history of diarrhea compared to healthy. The growth faltering cut-off criteria had a sensitivity of at least 53% to screen for diarrhea in infants between 6 and 12 months in shelters housing, but sensitivity was not adequate in corral housing. The standard infant growth charts produced in our study may be used as a clinician’s tool to detect diarrhea-associated growth deficits.