Abstract # 13333 Event # 218:

Scheduled for Saturday, August 24, 2019 02:45 PM-03:00 PM: (Room 309) Oral Presentation


STRESS RESPONSIVITY IN FEMALE CYNOMOLGUS MACAQUES (MACACA FASCICULARIS) CONSUMING WESTERN VERSUS MEDITERRANEAN DIET

C. A. Shively, S. E. Appt, M. Z. Vitolins, B. Uberseder, S. M. Day, M. G. Silverstein-Metzler and T. C. Register
Department of Epidemiology & Prevention, Wake Forest School of Medicine, Dept Pathology, Comparative Medicine, Medical Center Blvd., Winston-Salem, NC 27157-1040, USA
line
     We tested the hypothesis that Western (WEST) diet exacerbates, whereas Mediterranean (MED) diet ameliorates physiological stress responses. After a 7-month baseline, socially housed female cynomolgus macaques were fed a WEST (n=21) or a MED (n=17) diet for 31 months. Social status was determined monthly; social behavior was recorded 2X/week during 10 min focal samples. BP, 24 hour heart rates, cortisol (basal, in response to ACTH challenge, and to acute stress), were determined. 2 (dominant, subordinate) X 2 (WEST, MED) ANOVAs were conducted. There were no effects of diet or diet-status interactions on behavior (p’s>0.10). Subordinates received more aggression (p<0.0001), less grooming (p=0.027), and spent more time fearfully scanning (p=0.015) than dominants. Subordinates decreased and dominants increased SBP after 26 months (p=0.038). Heart rates in the MED group spiked sharply at meals (fed individually), and recovered significantly in between, whereas peaks/recoveries were less apparent in the WEST group (MED p=0.0008; WEST p=0.06). In the WEST group basal cortisol concentrations were lower in subordinates than dominants (p=0.006), but higher in subordinates than dominants in the MED group (p=0.01). The cortisol response to acute stress was lower in the MED than the WEST group (p=0.007). The WEST group had a greater cortisol response to ACTH than the MED group (p=0.02). Thus, WEST diet consumption may deleteriously impact health in part by exaggerating stress responses. Supported by NIH HL087103.