Abstract # 13418 Event # 121:

Scheduled for Friday, August 23, 2019 11:30 AM-11:45 AM: (Wisconsin Historical Society Auditorium) Symposium


IDENTIFICATION OF BIOMARKERS OF INFLAMMATION/AGING/STRESS IN NONHUMAN PRIMATES

L. D. Giavedoni1,2, L. M. Parodi1,2, J. Callery1 and V. L. Hodara1,2
1Texas Biomedical Research Institute, 8715 W Military Dr., San Antonio, TX 78227, USA, 2Southwest National Primate Research Center
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     A biomarker is a biological marker (DNA, RNA, protein, protein modification or metabolite) that reflects a biological state. It is a characteristic that is objectively measured and evaluated as an indicator of normal biologic processes, pathogenic processes or pharmacologic responses to a therapeutic intervention. Nonhuman primates (NHP) are the preferred animal models for pre-clinical research because they approximate humans in physiology and genetics more closely than any other animal. Cytokines are soluble mediators of the immune system that play a crucial role in intercellular signaling and in the recruitment of cells to inflammation sites, and that serve as biomarkers for conditions such as inflammation, aging, and stress. Identification of these molecules in NHP is crucial for the understanding of complex physiological and pathological mechanisms that occur in these species, and to demonstrate whether these mechanisms function similarly in humans. Multianalyte immunoassay (MAIA), where two or more analytes of one sample are measured simultaneously in a single assay, is a long-cherished goal for researchers due to work simplification, increased throughput, small sample volume, and reduced overall cost per test. The Luminex technology is one of these MAIA, and we have identified and validated Luminex reagents for the detection of multiple cytokines in Old and New World NHP, which have all contributed to enhancing the translational value of these animal models.