Abstract # 13440 Poster # 87:

Scheduled for Thursday, August 22, 2019 06:00 PM-08:00 PM: (Alumni Lounge) Poster Presentation


RISK FOR SELF-INJURIOUS BEHAVIOR AND THE RESPONSE TO STRESSFUL CHALLENGES: A RHESUS MACAQUE (MACACA MULATTA) MODEL EXAMINING GENOTYPE, HPA AXIS, AND BEHAVIORAL INTERACTIONS

R. Kruger1, E. K. Wood1, S. M. Day2, J. P. Day1, S. J. Suomi3 and J. D. Higley1
1Brigham Young University, Provo, Utah 84602, USA, 2Internal Medicine- Geriatrics & Gerontology, Wake Forest School of Medicine, Winston-Salem, NC 27023, 3Laboratory of Comparative Ethology, NICHD, NIH Animal Center, Poolesville, MD 20837
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     Given its association with stress and anxiety, this study assesses the relationship between serotonin transporter genotype (5HTT) and typologies of self-injurious behavior (SIB) in laboratory-living rhesus macaques. As in humans, a sizable percentage of rhesus macaques exhibit SIB (14-25%, depending on setting and rearing), making them ideally suited to study SIB. Subjects (N=161) were reared in one of three conditions (mother-reared (MR), peer-reared (PR), or surrogate peer-reared (SPR)), and were classified as self-biting (n=19) or non-self-biting (n=142). Subjects were genotyped for 5HTT genotype and their behaviors were recorded during an Intruder Challenge paradigm stressor. Results from a chi-square showed that SPR subjects were more likely to self-bite than the other groups (p<0.0001). Two-way ANOVAs with SIB status and 5HTT genotype as independent variables and plasma adrenocorticotropic hormone (ACTH) or behaviors during the social challenge as dependent variables showed significant SIB-status-by-5HTT genotype interactions (p>0.05). Self-biting subjects possessing the s allele exhibited impulsive and aggressive behavior, while self-biting subjects that were homozygous for the L allele exhibited high plasma ACTH and more time in stereotypies, suggesting different SIB typologies based on impulsivity or anxiety. These findings suggest that early rearing and 5HTT genotype may be important factors in understanding SIB etiology and typology.