Abstract # 1897 Event # 11:

Scheduled for Thursday, August 17, 2006 09:30 AM-09:45 AM: Session 2 (Regency East #2) Oral Presentation


K. L. Bales1, W. A. Mason1, S. R. Cherry2, C. Catana2 and S. P. Mendoza1
1University of California, Dept of Psychology and California National Primate Research Center, Davis, CA 95616, USA, 2Center for Molecular and Genomic Imaging, UC-Davis
     The numerous differences in rodent and primate neurobiology make a non-human primate model of the neuroendocrine basis of social bonding desirable. Titi monkeys (Callicebus cupreus) form strong pair-bonds, characterized by preference for a familiar partner and activation of the hypothalamic-pituitary-adrenal axis upon separation. We used functional neuroimaging in order to investigate baseline differences in brain metabolism of pair-bonded and non-bonded monkeys. Positron emission tomography (PET) technology using fluorodeoxyglucose (FDG) measures glucose metabolism, which reflects changes in functional synaptic activity. 16 conscious adult titi monkey males (4 that were housed alone, 12 that were pair-bonded) were used in this study. Males were injected with 1 mCi/kg of FDG, then returned to their cage; pair-bonded males were returned to their mates. Approximately 40 min later, the males were placed under anesthesia and scanned for 1 hour on a microPET P4 primate scanner. 3 of the 4 lone males were then introduced to a female and rescanned 48 hours later. Brain regions showing significant (p < 0.05) differences between lone males and those in pair-bonds included the nucleus accumbens, ventral pallidum, medial preoptic area, supraoptic nucleus of the hypothalamus, and hippocampus. In contrast, the caudate-putamen, insular cortex, mediodorsal thalamus and periaqueductal gray did not vary significantly in metabolic activity based on social status of the male. Supported by a pilot grant from the California National Primate Research Center.