Abstract # 204:

Scheduled for Saturday, August 19, 2006 11:15 AM-11:45 AM: Session 17 (Regency East #1) Oral Presentation

Age-dependent variation in behavior following acute alcohol administration in male and female adolescent rhesus macaques

M. L. Schwandt1, C. S. Barr1, S. J. Suomi2 and J. D. Higley1
1NIH/NIAAA, Laboratory of Clinical and Translational Studies, PO Box 529, Poolesville, MD 20837, USA, 2NIH/NICHD, Laboratory of Comparative Ethology
     Research has demonstrated that adolescence is an important period of development in terms of sensitivity to the intoxicating effects of alcohol. We investigated the relationship between age and the behavioral response to acute alcohol administration in a large sample of alcohol-naïve, adolescent rhesus macaques. Male and female subjects (n = 165; 74 males, 91 females) ranging in age from 24 to 48 months were administered an intravenous dose of alcohol. Subjects then underwent a 30-minute general behavioral assessment, followed by a 5-minute assessment of aggressive behavior. Behavioral data for each assessment (general and aggressive) were summarized using factor analysis. Rotated factor scores were used as dependent variables in multiple regression analyses to test for relationships between behavior and age at the time of testing. Both females and males exhibited negative correlations between age and general motor impairment (females: partial r = -0.622, p < 0.0001; males: partial r = -0.551, p = 0.0027). Females also exhibited positive correlations between age and impaired jumping ability (partial r = 0.309, p = 0.0375), and age and stimulation (partial r = 0.459, p = 0.0009), while males exhibited a positive correlation between age and aggressive behavior (partial r = 0.579, p < 0.0001). The results of this study indicate that age and sex are important factors to consider in studies of the adolescent response to alcohol.