Abstract # 171:

Scheduled for Friday, August 18, 2006 07:00 PM-09:00 PM: Session 17 (Regency West 1/3 ) Poster Presentation

A Genetics Resource & Informatics Program (GRIP) for the Oregon National Primate Research Center (ONPRC)

C. Dubay1, B. Ferguson2, S. Street1,2, S. Mitra1, H. Wright1, C. Khouangsathiene 1 and C. Pearson1
1OHSU Oregon National Primate Research Center, 505 NW 185th Ave, Beaverton, OR 97006, USA, 2Washington National Primate Research Center, University of Washington
     The Genetic Resources and Informatics Program (GRIP) was established at the Oregon National Primate Research Center (ONPRC) to provide genetic and bioinformatic resources and services for the researchers, staff, and managers of the center. The GRIP database (GRIPdb) gives our users Web based access to animal genomic information (e.g. genetic markers, alleles, haplotypes, and phenotypes). The Web interface also provides analytical tools such as pedigree visualization and kinship calculations based on parentage information from microsattelite marker genotypes. Additionally the GRIPdb supports Single Nucleotide Polymorphism (SNP) discovery and genotyping, providing an interface with dbSNP (www.ncbi.nlm.nih.gov/SNP) to automatically submit new SNP markers and data. Another genetic resource provided by the GRIP is the storage and cataloging of animal DNA samples in the GRIP DNA bank. Information on the banked samples is stored in the GRIPdb allowing researchers to view available samples for a particular animal, and to electronically request samples from the bank. The GRIPdb implements a robust security model managing roll based user access to data. The GRIPdb architecture allows individual data elements to be stored within a “project”. This allows all users have access to colony pedigree data, and to have other project specific data accessed only by those who have been granted access. This poster gives examples of how the GRIPdb and DNA bank are used to support research and colony management activities at ONPRC.