Abstract # 14:

Scheduled for Thursday, August 17, 2006 10:15 AM-10:30 AM: Session 2 (Regency East #2) Oral Presentation

Rate of floating limb activity at WaNPRC varies by sex, age, project assignment, and, in Macaca nemestrina, by origin

K. L. Bentson, R. U. Bellanca and C. M. Crockett
Washington National Primate Research Center, Box 357330, University of Washington, Seattle, WA 98195-7330, USA
     Over 15% of 1,074 monkeys >1 year old at the Washington National Primate Research Center during a one year period displayed floating limb activity (FLA). We defined FLA as “at least one unsupported leg is elevated without apparent volition and the monkey appears to notice and react to it or the monkey holds its toes at or above shoulder level for ? 5 seconds.” FLA is associated with self-biting: over 50% of self-biting monkeys exhibit FLA and over 50% of FLA monkeys self-bite. The incidence of FLA was not randomly distributed across the colony (GLM logistic regression and Scheffé post-hoc tests; factors = project assignment, sex, age group, and species: Macaca nemestrina, M. fascicularis, M. mulatta, Papio cynocephalus). Higher incidence of FLA occurred in monkeys on AIDS projects, in males, and in younger monkeys (p < 0.001). Logistic regression with the above factors except replacing species with origin was restricted to M. nemestrina (n = 609; n for some origin categories was small in other species). FLA varied by origin (p < 0.0001): M. nemestrina nursery-reared on-site had a higher incidence than ones from breeding colonies in Indonesia or Tulane. Identification of factors influencing the development of FLA may provide clues to underlying causes and treatments for FLA and self-biting and may be useful in deciding which monkeys to assign to long-term projects. NIH RR00166.