Abstract # 83:

Scheduled for Thursday, August 17, 2006 07:00 PM-09:00 PM: Session 8 (Regency West 1/3 ) Poster Presentation

Psychological Challenges During Pregnancy Alters the Autocorrelation Structure of Cardiovascular Rhythms In Both the Mother and Fetus in Macaque Monkeys (Macaca)

M. L. Miller1, M. S. Novak1, C. I. Kenney1, G. P. Sackett2, R. A. Woodward3, J. Bacher4 and S. J. Suomi1
1NIH-NICHD-LCE NIH Animal Center, P.O. Box 529, Poolesville, MD 20837, USA, 2Infant Primate Research Laboratory, Washington National Primate Research Center, University of Washington, Seattle, WA, 3NIH-NICHD-RAMB NIH Animal Center, 4NIH-ORS-DVR Bethesda, MD
     Prenatal experience can result in negative, null or positive changes to postnatal development. There are few data that identify and assess acute stress effects on the fetus. Measuring acute response to stressors is necessary to determine the mechanism of transferring maternal experience to the fetus. In this study, the acute cardiovascular responses to mild psychosocial challenges were assessed in four pigtailed and two pregnant rhesus macaques and their fetuses (M. nemestrina and M. mulatta, respectively). Maternal and fetal cardiovascular data were collected via chronic catheters from gestational day 129-153 for two minutes prior to and during an anticipate capture challenge. Data were collapsed into 5-second time blocks. Time series models (ARIMA) were fit to characterize individual differences in both the latency to respond and in changes to the autocorrelation structure of the data. For example, after correcting for autocorrelation in the data, acute fetal blood pressure responses were detected in response to 29/31 challenges. In addition, the autocorrelation patterns in maternal blood pressure changed more often than fetal blood pressure in response to the challenge episode [Sign Test p(18:23,0.56)=0.023]. These data suggest some aspects of maternal experience may not translate directly to the fetus. Future studies may benefit from increasing test frequency to better understand individual maternal and fetal response to stress. Supported by NCRR RR00166, NICHD 02274, and the intramural research program of NICHD.