Abstract # 178:

Scheduled for Friday, August 18, 2006 07:00 PM-09:00 PM: Session 17 (Regency West 1/3 ) Poster Presentation

Early growth and developmental data of three naturally conceived male rhesus macaques (Macaca mulatta) born to ART dams

L. Houser1, A. Dettmer2, G. Schatten 1 and L. Hewitson1
1Pittsburgh Development Center, 204 Craft Ave., Pittsburgh, PA 15213, USA, 2University of Massachusetts
     Assisted Reproductive Technologies (ART), such as in-vitro fertilization or intracytoplasmic sperm injection (ICSI), are commonly used in human fertility clinics. Sackett et al (at press) have used non-human primate models to demonstrate that there are no gross abnormalities in the early development of ART offspring. However, most individuals produced through ART have yet to reach adulthood. As no such information exists about their reproductive abilities, here we present early growth and developmental measures of three naturally conceived (NC) male rhesus macaques (Macaca mulatta) born to ART dams. These infants were compared to a control group of 12 NC infants (7 females and 5 males) born to NC dams and to a group of 10 infants conceived through ART (5 females and 5 males). Birth weight and weight gain through the first three months of life does not differ significantly between groups (p>0.05). The groups also showed no significant differences in neonatal reflex and sensorimotor development or in the attainment of object concept permanence (p>0.05). These data suggest that there are no generational effects on the early outcomes of offspring derived from ART dams. However, larger sample sizes and more longitudinal studies are necessary to substantiate these findings. This work was supported by grants from the NIH to G.S.