Abstract # 1996 Event # 202:

Scheduled for Saturday, August 19, 2006 10:15 AM-10:45 AM: Session 17 (Regency East #1) Oral Presentation


SOCIAL DRINKING IN FEMALE RHESUS MACAQUES: A PROFILE OF VOLUNTARY ORAL ETHANOL CONSUMPTION, REARING HISTORY, AND DOMINANCE RANKING

S. A. Chen1, W. W. Flint1, K. E. Iba1, S. J. Suomi2 and J. D. Higley1
1NIH/NIAAA-LCTS, NIH Animal Center, P.O. Box 529 Bldg 112, Poolesville, CA 20837, USA, 2NIH/NICHD-LCE
line
     The present study aimed to examine voluntary oral ethanol (EtOH) consumption in rhesus macaques. We hypothesized that given daily 1-h sessions, Ss would consume EtOH to the point of showing intoxication and preference for ethanol. Rearing history and dominance ranking were hypothesized to affect the amount of EtOH consumed. Mother-(MR) and peer-reared (PR) adolescent, female macaques were trained to consume EtOH by first exposing them to the aspartame-vehicle, until they freely consumed the vehicle. Thereafter, sufficient EtOH was added to produce an 8.4% EtOH water-aspartame solution for drinking (1 hr/day; 4-5 days/week) across 12 weeks. In the next two weeks, Ss were provided access to ethanol and vehicle ('preference test'). Results revealed a marked increase in EtOH intake on weeks 10-12 at a level (10.5 ml/kg/hr = ~0.7 g/kg/hr; n = 6; 5 PRs, 1 MR) consistently shown to produce blood ethanol concentrations above 0.08%. There was also a trend towards preference for consuming ethanol. Other cagemates (n = 6; 5 MRs, 1 PR) were consistent ‘nondrinkers’ (< 0.1 g/kg/hr) even after sustained training. ANOVA revealed that PRs consumed significantly more than EtOH than MRs across all 14 weeks of testing. ANOVA on collapsed dominance data revealed that medium to high level dominance ranking consumed significantly more than Ss with medium to low dominance ranking. These findings suggest that in a female-only social group, high alcohol consumption may be determined by early-life stress experience (peer-rearing) and current medium-high to high dominance ranking.