Abstract # 203:

Scheduled for Saturday, August 19, 2006 10:45 AM-11:15 AM: Session 17 (Regency East #1) Oral Presentation

Alcohol Consumption Across Multiple Non-Human Primate Species

S. Howell1, G. C. Westergaard1 and J. D. Higley2
1Alpha Genesis, Inc., P.O. Box 557, 95 Castle Hall Rd., Yemasee, SC 29945, USA, 2National Institute of Health/National Institute on Alcohol Abuse and Alcoholism
     The purpose of this project is to better understand alcohol consumption for nonhuman primates (NHP). While NHPs may not develop alcoholism per se, the study of alcohol consumption in NHPs will help dissect this complex disorder. Subjects included 44 primates representing multiple species (Cebus apella, Macaca mulatta, Macaca fascicularis), ages (juvenile, adolescent and adult), and sex (male, female). For rhesus, we also considered locale (captive, free-ranging). Data were collected at two South Carolina locales: Morgan Island Primate Center and Yemassee Primate Center. MI maintains ~3,000 free-ranging rhesus on a 192 hectare coastal sea island and YPC maintains about 1,200 primates in a conventional primate setting. Subjects were held in single cages for 10 days and provided one hour per day access to aspartame sweetened 8.4% ethanol solution. At Morgan Island, free-ranging rhesus macaque subjects were trapped and held in single cages for 10 days. An ANOVA method was used to consider the effects of age, sex, species and locale on alcohol consumption levels (grams consumed/kilogram body weight) (p <0.05). Results suggest rhesus macaques drank more than capuchins and cynomolgus macaques (F = 3.07, df = 2, p = 0.05). Juveniles drank more than adolescents and adults (F = 3.08, df = 2, p = 0.05) and males drank more than females (F = 6.68, df = 1, p = 0.01). For rhesus, captive males drank more than their free-ranging counterparts (F = 5.76, df = 1, p = 0.02). Results provide evidence that multiple species research can be valuable for understanding the complexities of alcohol consumption and alcohol related disorders.