Abstract # 199:

Scheduled for Saturday, August 19, 2006 08:30 AM-09:00 AM: Session 17 (Regency East #1) Oral Presentation

Prediction of Ethanol Self-Administration in Cynomolgus Monkeys

K. A. Grant1,2, I. Y. Leng3 and S. W. Gonzales4
1Oregon National Primate Research Center, 505 N.W. 185th Avenue, Beaverton, OR 97006, USA, 2Oregon Health & Science University, 3Wake Forest University School of Medicine, 4Biotic Micro
     The chronic and excessive drinking of alcoholic beverages is the behavioral basis of alcohol abuse and alcoholism. A scheduled induced polydipsia procedure was used to induce ethanol self-administration in 10 male cynomolgus monkeys (Macaca fascicularis). The procedure induced the daily consumption of water, 0.5 g/kg, 1.0 g/kg and 1.5 g/kg ethanol sequentially, in 30 consecutive sessions at each induction dose. In this manner, the monkeys learned to consume 4% ethanol in a graded fashion that avoided conditioned taste aversions, yet allowed many opportunities to associate drinking ethanol with intoxication (blood ethanol concentrations >0.100 mg/dl). During the induction of the highest dose of ethanol (1.5 g/kg), patterns of drinking were highly predictive of the daily consumption of ethanol over the next 12 months. The major predictor of establishing an eventual pattern of chronic (mean daily intakes >3.0 g/kg for 12 months) and excessive (binges of >4 g/kg/day) alcohol drinking was rapidly ingesting the equivalent of six drinks early in their drinking history (correlation 0.91). This animal model resembles diagnostic quantity and frequency measures for alcoholic drinking (i.e., drinking to intoxication) and can be used as a platform to identify biological risks for establishing harmful alcohol drinking and help develop interventions to reduce the risk of alcohol abuse and alcoholism.