Abstract # 186:

Scheduled for Friday, August 18, 2006 07:00 PM-09:00 PM: Session 17 (Regency West 1/3 ) Poster Presentation

Can we Predict the Metabolic Syndrome in Female Rhesus Macaques (Macaca mulatta)?

C. Swanson, G. R. Lubach, H. R. Crispen and C. L. Coe
Harlow Primate Laboratory, University of Wisconsin-Madison, 22 N. Charter St., Madison, WI 53715, USA
     Recent studies have demonstrated that certain people have a physiological profile, that increases their susceptibility to the “metabolic syndrome”. This syndrome refers to metabolic factors associated with obesity such as atherogenic dyslipidemia, high blood pressure, and insulin resistance. Furthermore, studies have suggested that prenatal nutrition and stressors may program the fetus to alter its metabolic setpoints, both pre- and postnatally. A rhesus monkey model was being developed to test the hypothesis that prenatal stress predisposes to this type of a physiological profile. In our pilot study, somatometric indices and blood chemistries (fasted and nonfasted) were obtained from adult females that had a period of prenatal disturbance (n = 8), or were from undisturbed pregnancies (n = 5). Ages ranged from 11-17 yr, and weights from 5-12 kg. Body Mass Index (BMI) was positively correlated with cholesterol levels (p < 0.005), whereas no correlation was found between weight and cholesterol levels (p < 0.70). In addition, abdominal circumference was positively correlated with low-density lipoprotein (LDL) (p < 0.02). In this initial analysis of females, there was no effect of prenatal condition on serum lipid levels. However, we are continuing to assess a larger number of females along with other indices of metabolic disorders.