Abstract # 133:

Scheduled for Friday, June 22, 2007 05:00 PM-07:00 PM: Session 14 (South Main Hall) Poster Presentation

A New Brain Atlas of the Common Marmoset and its Application to Infant Brain Development

W. M. Kenkel1, A. L. Quinn1, R. C. Bell1, E. C. Aronoff1, D. E. Bernhards1, A. C. Silva2 and J. D. Newman1
1Laboratory of Comparative Ethology, NICHD - NIH, NIH Animal Center, Poolesville, Maryland 20837, USA, 2CMU, LFMI, NINDS, NIH
     The developmental trajectory followed by the primate brain from infancy to adulthood can best be analyzed when landmarks of internal brain structure can be identified and compared at different ages. The common marmoset (Callithrix jacchus) is a small, primate with a brain the size of a rat’s and is commonly used in behavioral and neuroscience research, hence a road map of internal brain structures for identifying and tracking specific regions as they mature would find wide applicability. We have prepared a brain atlas from coronal sections taken from the brain of an adult female, using an existing atlas for this species and atlases for other New World species to label structures throughout the brain. The brains of two marmoset infants each at 1, 2 and 3 months of age were sectioned in the coronal plane, stained for Nissl granules and photographed with a Leica microscope and digital camera using Bioquant’s Life Sciences software. Comparisons of identified nuclei in the adult brain at forebrain and midbrain levels (e.g. hippocampus, lateral geniculate nucleus, amygdala, nucleus accumbens) with sections of corresponding regions of the infant brains showed a high degree of identifiability, suggesting that the adult brain atlas can serve as a useful road map not only for studies of adults brains but of the brains of developing individuals, as well.