Abstract # 152:

Scheduled for Friday, June 22, 2007 05:00 PM-07:00 PM: Session 14 (South Main Hall) Poster Presentation

Low-dose Oral Alcohol Self-administration Alters Social Interactions in Adolescent Cynomolgus Macaques (Macaca fascicularis)

C. A. Corcoran, P. J. Pierre and A. J. Bennett
Departments of Physiology/Pharmacology and Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC 27127, USA
     Previous research has shown a loosening of social constraints and enabling of social interaction between animals with low-dose alcohol consumption. We examined the effect of low-dose (<1.0g/kg) oral alcohol self-administration on social behavior in eight adolescent male cynomolgus monkeys. Animals were housed in triplets or groups of four, and were individually trained to consume EtOH in ascending concentrations of 1%, 2%, and 4% at doses of 0.5g/kg and 1.0g/kg. Animals were reunited with their cagemates following self-administration session in adjacent room. Fifteen minutes after reunion, five-minute live focal animal observations were collected between 60 and 120 minutes post-consumption. Baseline data was collected for seven weeks/one day per week, EtOH behavior was collected for eleven weeks/three days per week. Social behavior was significantly influenced by alcohol consumption. Alcohol consumption did not influence the amount of time spent in social proximity [t(14)=-1.3, p>0.20]. Grooming duration was increased after EtOH [t(14)=-2.45, p<0.05]. The frequency of aggression was not altered [t(14)=-0.75, p>0.45]. Preliminary observations suggested that incidences of increased aggression occurred upon initial reunion, which was not captured during formal observations. An additional study is underway to determine whether increased grooming follows a brief increase in aggression following initial reunion. Taken together, our data are consistent with previous reports and demonstrate an alteration in specific aspects of social interaction in adolescent monkeys following low-dose alcohol consumption. Supported by NIH grants AA13995; AA011997.