Abstract # 131:

Scheduled for Friday, June 22, 2007 05:00 PM-07:00 PM: Session 14 (South Main Hall) Poster Presentation

MonkeySNP: A Web Portal Mirroring dbSNP Data on Rhesus Macaque (MACACA MULATTA) Single Nucleotide Polymorphisms (SNPs)

C. Dubay1,2, C. Pearson1, S. Khouangsathiene1 and B. Ferguson1,3
1Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 18th Avenue, Beaverton, OR 97006, USA, 2Department of Medical Informatics & Clinical Epidemiology, Oregon Health & Science University, 3Washington National Primate Research Center, University of Washington
     MonkeySNP is a website created by the GRIP at the ONPRC to facilitate access to rhesus SNP data mirrored from dbSNP. The dbSNP database is a public collection of simple polymorphisms (e.g. SNP and insertion/deletion) hosted by the National Center for Biotechnology Information (NCBI). MonkeySNP can present population specific genotype data which is modeled in the dbSNP data schema, but is not always included in dbSNP submissions. Researchers are able to compare SNPs in Indian and Chinese Rhesus populations through comprehensive reports on observed genotypes and allele frequencies, organized by gene or genomic region. MonkeySNP allows a user to search for SNPs by Gene Name/EntrezGene ID, dbSNP ID, proximity to another marker or gene, and allele frequency. Search results provide a list of SNPs with hyperlinks to detailed SNP information, including flanking sequences, population genotypes, and frequencies. SNPs can also be viewed by visual genotype showing major and minor alleles observed by population. This visual genotype is interactive allowing researchers to identify appropriate SNPs (e.g. Tag SNPs) for their needs. In summary, MonkeySNP is a mirror of dbSNP containing additional rhesus sub-population genotype data and visual tools supporting SNP identification and selection.