Abstract # 65:

Scheduled for Friday, June 20, 2008 10:15 AM-10:25 AM: Session 7 (Meeting Room 2DEF) Oral Presentation

Fractures Associated with Breeding in a Colony of SPF Cynomolgus Macaques (Macaca fascicularis)

S. Howell, A. Saucedo, K. Rivas, M. Daniel, J. Larin and J. Wagner
Mannheimer Foundation, Inc., Haman Ranch, P.O. Box 1235, Clewiston, FL 33440, USA
     The¬†purpose of this report is to consider the etiology of recent fractures in young female cynomolgus macaques in our SPF breeding colony. Subjects included four females aged 2.78 to 4.25 years of age housed in enriched outdoor social groups. Data includes medical treatment and diagnostic testing results that include radiographs, dexascans, and comparison of bone density. In addition, colony management records were reviewed to include social group compositions, prior experience, and research history. Results suggest a unique pattern of bilateral tibia/fibula fractures for these females. Bone density analyses indicated subjects were similar to their age/sex matched controls. However, females shared several common traits. First, they all had prior biomedical research experience. Second, they were newly introduced to larger bodied male breeding partners (females:2.85 to 3.45 kg; males:6.33 to 9.81 kg). That is, the males were more than twice the weight of the females. Last, all females copulated with their new male partners. Results suggest that copulatory posture may have facilitated breakage in these relatively small females. Careful attention to females upon introduction to new social partners is suggested particularly for young females with a history of single housing in biomedical research. Slow acclimation to new social partners may help prevent lower limb fractures.