Abstract # 2390 Event # 17:

Scheduled for Thursday, June 19, 2008 11:00 AM-11:10 AM: Session 2 (Meeting Room 1GHI) Oral Presentation

Cardiac Troponin I and Brain-type Natriuretic Protein are Associated with cardiovascular disease in Chimpanzees (Pan troglodytes)

J. Ely, M. L. Lammey and D. R. Lee
Alamogordo Primate Facility, Holloman AFB, NM 88330-0956, USA
     Chimpanzee cardiovascular disease (CVD), the primary cause of mortality in captivity, differs clinically from human ischemic CVD (heart attack, myocardial infarction).  Our objective was to identify biomarkers to distinguish chimpanzees with CVD prior to clinical presentation of advanced disease.  Examinations by a veterinary cardiologist identified 28 chimpanzees with CVD (cardiomyopathy, arrhythmias, valvular disease).  Biomarkers included lipid panel, high-specificity C-reactive protein (hs-CRP), B-type natriuretic protein (BNP) and cardiac troponin I (CTnI).  First we studied the association of CTnI and HS-CRP with disease severity in 17 chimpanzees trichotomized by disease severity (Normal, Mild, Moderate).  We used Analysis of Variance on log-transformed CTnI and hs-CRP data to test for group differences.  hs-CRP was not associated with disease severity [F(1,9)=0.50, p=0.50] but CTnI was significant [F(2,12)=6.04, p=0.02].  Secondly, we assayed 28 CVD cases and their controls for all 4 biomarkers in a prospective case-control study.  Results indicated no differences between Cases and Controls for lipids or CRP.  Cases had higher BNP levels than Controls [F(1,49)=7.95, p=0.007].  Case/Control status was also significantly associated with CTnI levels [G(21)=6.33, p=0.012], with Cases 4.2 times more likely than Controls to have elevated CTnI.  Neither CRP nor lipids were associated with chimpanzee CVD, because chimpanzees die from hypertension-related myocardiofibrosis.  CTnI and especially BNP offer great utility for CVD monitoring and detection in chimpanzees.  Such comparative studies offer insight into the etiology of human CVD.