Abstract # 89:

Scheduled for Friday, June 20, 2008 05:00 PM-07:00 PM: Session 12 (Ball Rooms A and B) Poster Presentation

Relations among body composition, activity, hematology, and age in male common marmosets: toward a model of frailty

C. N. Ross1, S. Tardif1, K. Davis2, G. Dobek3 and K. Brasky4
1Barshop Institute for Longevity & Aging, University of Texas Health Science Center, 15355 Lambda Dr, STCBM Bldg, Ste 3.325, San Antonio, TX 78245-3207, USA, 2Cedarville University, Cedarville, OH, 3College of Veterinary Medicine, Texas A&M University, College Station, TX, 4Southwest National Primate Research Center, San Antonio, TX
     There are limited animal models of the frailty process. As part of an effort to examine the potential value of the common marmoset (Callithrix jacchus) as a small primate model of frailty, we characterized relations among variables associated with frailty modeling in humans. The following variables were measured in a population of 30 male marmosets, ranging in age from 2 to 13.5 years: body composition (body mass, fat mass, lean mass), activity (scored during behavioral observations), basic hematology, and C-reactive peptide concentration. Age was negatively correlated with body mass [r(28)=-0.43, p=0.02] and lean mass [r(28)=-0.37, p=0.05], but not correlated with fat mass. Age was negatively related and lean mass was positively related to hemoglobin concentration [N=30, r2=0.43, p<0.001] and albumin concentration [N=30, r2=0.49, p<0.001]. C-reactive peptide was not related to age, but showed a U-shaped relation to fat mass. Time spent inactive was not related to age but showed a trend toward a negative relation with lean mass [r(28)=-0.33, p=0.08]. These relations among body composition, hematology, and activity suggest that the marmoset is worthy of further consideration and characterization as a potential frailty model.