Abstract # 2410 Poster # 89:

Scheduled for Friday, June 20, 2008 05:00 PM-07:00 PM: Session 12 (Ball Rooms A and B) Poster Presentation


Relations among body composition, activity, hematology, and age in male common marmosets: toward a model of frailty

C. N. Ross1, S. Tardif1, K. Davis2, G. Dobek3 and K. Brasky4
1Barshop Institute for Longevity & Aging, University of Texas Health Science Center, 15355 Lambda Dr, STCBM Bldg, Ste 3.325, San Antonio, TX 78245-3207, USA, 2Cedarville University, Cedarville, OH, 3College of Veterinary Medicine, Texas A&M University, College Station, TX, 4Southwest National Primate Research Center, San Antonio, TX
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     There are limited animal models of the frailty process. As part of an effort to examine the potential value of the common marmoset (Callithrix jacchus) as a small primate model of frailty, we characterized relations among variables associated with frailty modeling in humans. The following variables were measured in a population of 30 male marmosets, ranging in age from 2 to 13.5 years: body composition (body mass, fat mass, lean mass), activity (scored during behavioral observations), basic hematology, and C-reactive peptide concentration. Age was negatively correlated with body mass [r(28)=-0.43, p=0.02] and lean mass [r(28)=-0.37, p=0.05], but not correlated with fat mass. Age was negatively related and lean mass was positively related to hemoglobin concentration [N=30, r2=0.43, p<0.001] and albumin concentration [N=30, r2=0.49, p<0.001]. C-reactive peptide was not related to age, but showed a U-shaped relation to fat mass. Time spent inactive was not related to age but showed a trend toward a negative relation with lean mass [r(28)=-0.33, p=0.08]. These relations among body composition, hematology, and activity suggest that the marmoset is worthy of further consideration and characterization as a potential frailty model.