Abstract # 2423 Poster # 52:

Scheduled for Thursday, June 19, 2008 05:00 PM-07:00 PM: Session 4 (Ball Rooms A and B) Poster Presentation

Stability of central monoamine metabolite concentrations in adolescent chimpanzees

M. B. Fontenot1, S. D. Breaux1, S. L. Watson3 and G. M. Anderson2
1New Iberia Research Center, Division of Behavioral Sciences, University of Louisiana at Lafayette, Lafayette 70560, USA, 2Child Study Center, Yale University School of Medicine, New Haven, CT 06520, 3Department of Psychology, University of Southern Mississippi, Hattiesburg MS 39406
     Numerous studies have associated low central serotonin function and impulsive, aggressive and antisocial behavior in humans. Specifically, lower levels of cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA, the principal metabolite of serotonin), has been associated with criminal behavior, substance abuse, and increased mortality from murder or suicide. We examined the longitudinal stability of CSF 5-HIAA and homovanillic acid (HVA, the major dopamine metabolite), as well as the effects of age and sex on the measures. Two CSF samples were obtained 6 months apart from 11 chimpanzees (Pan troglodytes) aged 4.8 – 8.8 yrs. Metabolite concentrations were determined using HPLC. We found that CSF 5-HIAA levels at the two timepoints were highly correlated [Pearson’s r, a=0.05], as were the two HVA concentrations. Both 5-HIAA and HVA levels were significantly correlated negatively with age [Pearson’s r, a=0.05]. Results of a mixed–model ANCOVA, covarying for age, indicated that CSF 5-HIAA concentrations were significantly higher in females (n=5) compared to males [n=6; a=0.05]. These results indicate that CSF 5-HIAA and HVA levels in chimpanzees are stable within individuals, that concentrations decline from 5 to 9 years of age, and that sex effects on CSF 5-HIAA are substantial. The results are congruent with prior reports of the measures in humans and may help to understand the neurochemistry underlying aggressive, impulsive behavior.