Abstract # 2507 Poster # 66:

Scheduled for Saturday, September 19, 2009 06:30 PM-09:00 PM: Session 5 (Mission Bay Ballroom CDE) Poster Presentation


DEVELOPMENT OF THE BASAL GANGLIA IN CAPUCHIN MONKEYS (CEBUS APELLA)

K. A. Phillips1, C. A. Sobieski4, V. R. Gilbert4, C. Chiappini-Williamson4, C. C. Sherwood2 and P. L. Strick3
1Trinity University, Department of Psychology , San Antonio, TX 78212, USA, 2The George Washington University, 3University of Pittsburgh, 4Hiram College
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The basal ganglia are subcortical structures involved in the planning, initiation and regulation of movement as well as a variety of non-motor, cognitive functions. As the basal ganglia are believed to be affected in neurodevelopmental disorders such as ADHD and Tourette’s, understanding the normal development of these brain structures is necessary. Nonhuman primates share several important characteristics of development with humans, including a prolonged infancy and juvenile period, long lifespan and complex social behavior, making them ideal models for developmental psychopathology. Here we report the development of the basal ganglia (caudate, putamen and globus pallidus) in brown capuchin monkeys. We describe, from a cross-sectional sample, brain development in 29 brown capuchin monkeys [male n=18, female n=11; age range=4 days–20 years] using high-resolution structural MRI. The raw volumes of the putamen [ANOVA; p=0.04] and caudate [ANOVA; p=0.009] were significantly effected by the covariate age. There were no effects of the variable sex. Quadratic growth trajectories best explained the developmental change observed in the putamen [p=0.02]. Developmental changes in the caudate were similarly explained by linear and quadratic growth trajectories [p=0.02]. These observed developmental patterns are similar to humans and suggest that capuchin monkeys are excellent models for human developmental psychopathology.