Abstract # 229:

Scheduled for Monday, September 21, 2009 01:45 PM-01:55 PM: Session 25 (Del Mar Room) Oral Presentation


CONTRIBUTIONS AND CURRENT USES OF CHIMPANZEES IN BIOMEDICAL RESEARCH

C. R. Abee1, E. N. Videan2 and S. M. Zola3
1UT M. D. Anderson Cancer Center, Michale E. Keeling Center for Comparative Medicine and Research, 650 Cool Water Dr., Bastrop, TX 78602, USA, 2Alamogordo Primate Facility, Charles River Laboratories, Alamogordo, NM, 3Yerkes National Primate Research Center, Emory University, Atlanta, GA
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Chimpanzees (Pan troglodytes) have contributed to research benefiting human and animal health for more than a century. Chimpanzees have been crucial in the fight against human disease, the development of new drug therapies and the safety and efficacy of those therapies. Notable examples of medical advances that required chimpanzees include the development of polio, hepatitis A, and hepatitis B vaccines, as well as some of the monoclonal antibodies that have revolutionized medical treatment of cancer and autoimmune diseases. Currently, chimpanzees are used for developing vaccines and drugs for hepatitis C, which affects 300 million people worldwide, and better vaccines for hepatitis B, which affects 800 million people worldwide. They are also used for testing vaccines and anti-viral therapies for HIV. Within the last two years, significant medical progress has been made using chimpanzees in hepatitis and other infectious and non-infectious diseases, such as Alzheimer’s, human immunodeficiency virus (HIV), dengue fever, malaria, and respiratory syncytial virus. In addition, chimpanzee derived stem cell research shows promise as an alternative to human stem cell research. Hundreds of millions of human lives have been enhanced in quality and duration though medical research conducted with chimpanzees.