Abstract # 198:

Scheduled for Monday, September 21, 2009 09:45 AM-09:55 AM: Session 19 (Del Mar Room) Oral Presentation


POSSIBLE QUANTITATIVE TRAIT LOCI FOR IMPULSIVITY IN VERVET MONKEYS

L. Fairbanks1, S. Service1, M. J. Jorgensen2, J. N. Bailey1, S. Breidenthal1, A. J. Jasinska1 and N. B. Freimer1
1Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA 90024, USA, 2Wake Forest University Health Sciences
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     Impulsivity is dimension of temperament that is related to life history outcomes in nonhuman primates and to vulnerability for psychopathology in humans. The Intruder Challenge test has been used to characterize individual differences in impulsivity for a sample of 633 vervet monkeys (Chlorocebus aethiops sabaeus) from the extended multigenerational pedigree of the Vervet Research Colony, for a study of genetic influences on impulsivity-related traits. A lifetime Social Impulsivity score for each individual was calculated from age and sex adjusted measures averaged across different life stages. Here we report the initial results from quantitative trait linkage (QTL) analyses using 260 microsatellite markers distributed over the vervet genome. Two point QTL analysis, using SOLAR, identified two possible susceptibility regions for Social Impulsivity. A marker on vervet chromosome 3 had a log odds ratio of 3.0 for linkage to the lifetime Social Impulsivity score for the sample as a whole. A second region, on vervet chromosome 11, had LOD scores > 2.2 on two adjacent markers 6 centimorgans apart for male and juvenile Social Impulsivity scores, with LOD’s > 1.6 on flanking markers. Fine mapping at these loci is proposed to refine the susceptibility regions and identify the specific genes involved.