Abstract # 2823 Poster # 81:

Scheduled for Friday, June 18, 2010 07:00 PM-09:00 PM: Session 18 (Medallion Ballroom C/D/E/F) Poster Presentation


T. L. Koban1, S. J. Schapiro2, T. Kusznir1, S. P. Lambeth2, J. Ogbin1 and E. Garofalo1
1Huntingdon Life Sciences, Veterinary Services Department, Mettlers Rd, East Millstone, NJ 08875, USA, 2The Michael E. Keeling Center for Comparative Medicine and Research, The University of Texas M.D. Anderson Cancer Center, Bastrop TX 78602 USA

Macaque species are the most versatile of all nonhuman primates, thriving and adapting in various environments. Of the 22 macaque species, cynomolgus macaques are the nonhuman primate most commonly used in research worldwide. The present study investigates the effects of a habituation program on 20 (M=10; F=10) cynomolgus monkeys after an international journey from China, through quarantine in the USA, and relocation to their final destination. One-half of the animals were housed with a social partner and one-half were singly housed on initial arrival in quarantine. These housing arrangements were consistent from quarantine to final destination. Serum cortisol was collected at seven time points during this journey: China (1), quarantine (2, 3) and final destination (4, 5, 6, 7). The duration between each time point was approximately 2 weeks. We used a mixed model 2x2(x7) ANOVA, looking at sex, housing and time point. There was a significant sex and time point interaction and a trend for an interaction between sex and housing [P<0.06]. All females displayed a significant decrease in cortisol between time point 4 and 7. All males showed a significant decrease in cortisol between time point 4 and 6. These results indicate that international transportation affects cortisol values in cynomolgus monkeys and that habituation programs may be beneficial to nonhuman primates in their acclimation to a research environment, although results may vary by sex.