Abstract # 14:

Scheduled for Thursday, June 17, 2010 10:00 AM-10:10 AM: Session 3 (Medallion Ballroom B) Oral Presentation


SIMILARITY IN TEMPERAMENT BETWEEN RHESUS MONKEY (MACACA MULATTA) MOTHERS AND OFFSPRING IS ASSOCIATED WITH SIMILARITY IN MONOAMINE OXIDASE A GENOTYPE

E. C. Sullivan1,2 and J. P. Capitanio2
1University of California Davis, Department of Psychology, One Shields Avenue, Davis, CA 95616, USA, 2California National Primate Research Center
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We have previously reported that sons exhibit temperament characteristics that are more strongly correlated with those of their mother than do daughters, when evaluated through the same assessment at comparable ages. We hypothesized that greater similarity in temperament between sons and their mothers may be due in part to the monoamine oxidase A gene, MAOA, and its location on the x-chromosome. Temperament ratings were conducted on 3-4 month old rhesus monkeys at the conclusion of a standardized 25-hour biobehavioral assessment. Factor analysis of ratings revealed a four factor temperament structure. Results indicate that offspring sharing the same genotype with their mother in the promoter region of this gene, MAOA-LPR, show stronger offspring-mother temperament factor score correlations than those only sharing one allele, F(3,60)=5.524, P=0.002; Daughter-mother pairs sharing identical MAOA-LPR genotype [n=14] show the strongest correlations, followed by hemizygous son-homozygous mother pairs [n=19], hemizygous son-heterozygous mother pairs [n=33], and then daughters sharing one allele with their mother [n=37]. This pattern reflects the degree of offspring-mother genetic similarity; sons have only one copy of the allele (from their mother) and are more similar in temperament to their mothers than are daughters, who also inherited an allele from their father. However, females who share both alleles with their mother show the strongest correlations, suggesting that there is a dosage effect of MAOA-LPR genotype on similarity in temperament.