Abstract # 49:

Scheduled for Thursday, June 17, 2010 07:00 PM-09:00 PM: Session 11 (Medallion Ballroom C/D/E/F) Poster Presentation


P. Pierre, C. A. Corcoran, M. Blevins and A. J. Bennett
Wake Forest Health Sciences, Medical School Blvd, Winston-Salem, NC 27157, USA

Nonhuman primates provide a unique opportunity for controlled, longitudinal study of the effects of alcohol on behavioral and physiological development. The effects of alcohol self-administration on behavioral activity were evaluated in adolescent male cynomolgus monkeys (Macaca fascicularis). Monkeys orally self-administered alcohol (1.0 g/kg) in a concentration of 6% sucrose-solution or an isocaloric vehicle in a 30 min limited-access procedure 5 days/week. The procedure met the criteria for adolescent binge-drinking in terms of subject development, drinking frequency, and achieved blood alcohol levels. Activity was measured continuously using a wrist watch actimeter prior to, and throughout, 12 months of drinking. Between-within RMANOVA was performed on the activity data. Drinking group differences were not evident in total activity in light and dark periods; however, the organization of activity within the dark period differed significantly between the groups [P<0.05]. The activity drop-off at the onset of the dark phase was decreased in drinkers and the effect became more pronounced with cumulative drinking [P<0.05]. Similar dysregulation was shown by increased frequency of activity disruptions in the drinkers during the dark phase, an effect that also became more pronounced with continued drinking across the 12 months [P<0.05]. Finally, the morning spike in activity was delayed in drinkers as compared to the non-drinkers [P<0.05]. Taken together, our data provide evidence of alteration of activity patterns associated with alcohol consumption.