Abstract # 2960 Event # 22:

Scheduled for Thursday, June 17, 2010 11:00 AM-12:00 PM: Session 6 (Mezzanine Ballroom A/B/C/D) Roundtable


MACAQUE DIVERSITY: IMPLICATIONS OF GENETIC VARIATION FOR RESEARCH TO ADVANCE INDIVIDUALIZED HEALTH CARE

P. Houghton1 and J. Erwin2
1Primate Products, Inc., Woodside, CA, USA, 2Virginia-Maryland Regional College of Veterinary Medicine at Virginia Tech.
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About twenty species of macaques are recognized, along with many sub-specific and isolated populations. Intergradation exists within some population boundary zones, as well as between some sympatric species. The existence of hybrid zones generates questions about speciation, isolating factors, population ranges, niche adaptations, conservation status, and other issues. Macaques originating from various source populations are often mixed together in breeding colonies, and some of these are already from intergrade zones. Especially notable are those from the Macaca mulatta X M. fascicularis intergrade zone in central southeast Asia. These are usually sold as fascicularis, but they resemble mulatta. Macaque origins sometimes play a role in selection of research subjects, due to beliefs about differing population-based characteristics (e.g., Chinese vs. Indian origin rhesus). As we move closer to genome-based individualized medicine, the biological integrity and population origins of the primates involved in biomedical and behavioral research becomes increasingly and critically important. A collaborative effort is proposed that would promote characterization and increase understanding of genomic and phenomic variation within and across macaque populations. The organizers invite participation in the discussion and in the collaborative project.