Abstract # 39:

Scheduled for Saturday, September 17, 2011 02:40 PM-03:00 PM: Session 9 (Meeting Room 410) Oral Presentation


RESTING-STATE FUNCTIONAL CONNECTIVITY IN CAPUCHIN MONKEYS (CEBUS APELLA)

K. A. Phillips1,2,3, H. Wey3, N. Holder1 and P. Kochunov2,3
1Trinity University, Department of Psychology , San Antonio, TX 78212, USA, 2Southwest National Primate Research Center, 3University of Texas Health Sciences Center at San Antonio
line
     

Functional connectivity is inferred from spontaneous blood-oxygen-level dependent (BOLD) signal fluctuations arising from low frequency (<0.1Hz) brain activity. Spatially distinct regions with synchronized brain activity comprise resting-state networks (RSNs). In this study, we identify RSNs in capuchins and compare these with the well-documented RSNs in humans. We hypothesize that the fundamental RSNs, such as the primary sensory-motor networks and the default mode network, will be most similar between species, while networks related to complex behaviors, such as language, will show the greatest difference. Fifteen resting-state fMRI were acquired from five anesthetized capuchins (4 males, 1 female). Data on humans was derived from de-identified normal subjects (17 males, 26 females) whom were instructed to close their eyes and rest during fMRI scans. Temporal-concatenated independent component analysis was performed using the MELODIC toolbox in FMRIB Software Library. Twenty independent components (IC) were pre-defined for the number of output networks. Spatial correlation coefficients between the ICs of capuchins and humans were calculated after co-registration. As predicted, fundamental RSNs including the visual, auditory, default-mode, sensory-motor and executive control networks were identified in both species. Spatial correlation analysis of all ICs between capuchins and humans revealed 5 IC pairs with high correlation, confirming networks identified through visual inspection. This study demonstrates for the first time the RSNs in anesthetized capuchins and suggests that RSNs of primary systems and the default-mode network are conserved across primates.