Abstract # 38:

Scheduled for Saturday, September 17, 2011 02:20 PM-02:40 PM: Session 9 (Meeting Room 410) Oral Presentation


FUNCTIONAL IMAGING OF PAIR-BOND FORMATION IN THE COPPERY TITI MONKEY (CALLICEBUS CUPREUS)

N. Maninger1, K. Hinde1,2, S. P. Mendoza1,3, W. A. Mason1, S. R. Cherry4 and K. L. Bales1,3
1California National Primate Research Center, One Shields Ave, Davis, CA 95616, USA, 2Department of Human Evolutionary Biology, Harvard University, 3Department of Psychology, University of California, Davis, 4Department of Biomedical Engineering, University of California, Davis
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     Titi monkeys (Callicebus cupreus) form strong pair-bonds, characterized by selective preference for their partner, mate guarding, physiological and behavioral agitation upon separation, and social buffering. The goal of the current study was to examine what brain regions are involved in pair-bond formation using functional imaging. We examined changes in central glucose uptake in adult males before and 7 days after being paired with a female, and compared these time points in lone males that served as age-matched controls. Positron emission tomography (PET) registered with structural magnetic resonance imaging (MRI) was used to investigate central glucose uptake. Animals were injected with 1 mCi/kg of fluorodeoxyglucose (FDG), returned to their cage for 30 min of conscious uptake, placed under anesthesia, and then scanned for 1 hour on a microPET P4 primate scanner. Paired males (n=7) were housed with their female pair-mate for the uptake period, while control males (n=6) were housed alone. Using mixed models analysis, we found significant (p<0.05) changes in glucose uptake with pair-bond formation in the “reward” circuitry (ventral pallidum) and “social recognition” circuitry (medial amygdala). We also found significant changes in the paraventricular nucleus of the hypothalamus, which is involved in the release of oxytocin, vasopressin, and corticotropin-releasing hormone – these hormones are involved in pair-bond formation and stress in rodents. Supported by: Good Nature Institute, NIH RR00169 and HD053555.