Abstract # 3148 Event # 154:

Scheduled for Sunday, September 18, 2011 04:45 PM-05:00 PM: Session 22 (Meeting Room 410) Oral Presentation


COMPARATIVE ANALYSIS OF LENGTH POLYMORPHISMS IN THE PROMOTER REGION OF THE SEROTONIN TRANSPORTER GENE (SLC6A4) IN CERCOPITHECIDAE

N. D. Simons, S. Winters and J. G. Lorenz
Central Washington University, Dean Hall 334, Ellensburg, WA 98926, USA
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The serotonin transporter gene (SLC6A4) is a critical component in the serotonergic system. Sequence variation in SLC6A4, particularly VNTR length polymorphisms in the promoter region (referred to as 5-HTTLPR) have been associated with a number of neuropsychiatric-related phenotypes in humans and behavioral phenotypes associated with stress and aggression in rhesus macaques. Here we present a comparative analysis of length polymorphisms in the promoter region of SLC6A4 in 26 species across 13 genera of nonhuman primates within the family Cercopithecidae (n=306). Our results indicate length polymorphisms in 30.1% (n = 8) of species, which is more variation than previously thought. In polymorphic species the two common alleles are long (L) and short (S), with average genotype frequencies of 73.5% (L/L), 11.8% (S/S) and 14.7% (L/S). While allele frequencies do vary across polymorphic species, the frequency of the homozygous (S/S) genotype ranges from 4.34% in the Indian rhesus macaque (Macaca mulatta) to 83.33% in the Olive baboon (Papio anubis). The homozygous (S/S) and heterozygous (L/S) genotypes are of interest because they are associated with reduced transcription efficiency. Individuals with (L/S) and (S/S) genotypes have significantly lower maximal uptake of serotonin than (L/L) genotypes. These results therefore have implications for our understanding of inter-species behavioral variation.