Abstract # 147:

Scheduled for Sunday, September 18, 2011 05:00 PM-05:15 PM: Session 20 (Salon F (Sixth Floor)) Oral Presentation


EFFECT OF TESTOSTERONE ON COGNITION IN AGED MALE RHESUS MONKEYS

A. Lacreuse1, B. J. Kelly2, V. Maguire-Herring2, K. M. Stonemetz2 and M. A. Novak1,2
1University of Massachusetts, Department of Psychology, Amherst, MA 01003, USA, 2Harvard Medical School, NEPRC, Southborough, MA 01772, USA
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While several studies have shown that estrogens improve selective cognitive domains in aged female macaques, it is not known whether androgens have similar effects in males. We present the first data from an ongoing project focusing on the effects of testosterone (T) manipulations on cognition in aged male rhesus monkeys (Macaca mulatta). Eight aged males (average 19 years old), were tested in tasks of visual recognition memory, working memory and spatial memory under three hormonal conditions lasting 4 weeks each: (1) when intact at baseline (2) when treated with the Gonadotropin-Releasing Hormone agonist Depot Lupron (200 µg/kg) and add-back of T enanthate (20 mg/kg) and (3) when treated with Depot Lupron + oil vehicle in a cross-over design. Using mixed-model repeated measures analysis of variance, their performance was compared to that of 6 young male rhesus monkeys (5-6 years old) previously tested in the same paradigm (Lacreuse et al, Physiology and Behavior, 2009). Although age-related cognitive impairment was evident in all tasks, T administration did not significantly affect cognitive function in the old males. These results are consistent with recent human data suggesting that T does not benefit cognition in older men. Supported by the American Federation for Aging Research.