Abstract # 3187 Poster # 180:

Scheduled for Sunday, September 18, 2011 07:00 PM-09:00 PM: Session 23 (Salon G (Sixth Floor)) Poster Presentation


EARLY TEMPERAMENT PREDICTS ALCOHOL INTAKE IN GROUP-HOUSED RHESUS MACAQUES

K. Orgad1, M. S. Gibson1, A. C. Chaffin1, S. J. Suomi3, C. S. Barr2, M. L. Schwandt2 and J. D. Higley1
1Brigham Young University, Department of Psychology and Neuroscience, Provo, UT 84602, USA, 2NIH Animal Center, NIAAA, LCTS, Poolesville, MD 20837, 3NIH Animal Center, NICHD, LCE
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Type 1 alcoholism is characterized by high alcohol intake to mediate anxiety, and Type II alcoholism is characterized by impulsive, antisocial behavior. This study is an assessment of early life behaviors that characterized both temperamental types (anxiety and impulsive temperaments) as predictors of adult alcohol intake. Subjects were 76 mother-reared subjects (Macaca mulatta), first observed from birth until five months of age, twice a week for a total of 10 minutes per week, using an objective behavioral scoring system designed to represent anxiety and sociality. The average duration of each behavior was computed for the third, fourth, and fifth months of life and these measures were correlated with future alcohol consumption measured 3-4 years later in adolescence or adulthood (3-5 years of age). With weight, age, and drinking situation (drinking alone or in groups) controlled, multiple regressions were used to assess whether behaviors were predictive of high alcohol intake. Results: Monkeys low in social contact, aggression, and environmental exploration, and freezing, that spent more time being cradled by mother showed high alcohol intake. Partial correlation values ranged from .702 to .744, and significant p-values ranged from 0.0009 to 0.031, with social contact approaching significance (p<0.07). Our data show that in mother-reared subjects, early life behaviors that characterize both Type 1 and Type 2 temperament are predictive of alcohol intake.