Abstract # 3513 Poster # 51:

Scheduled for Thursday, June 21, 2012 07:00 PM-09:00 PM: Session 9 (Gardenia) Poster Presentation


THE EPIDEMIOLOGY OF NON-PATHOGENIC DIARRHEA IN CAPTIVE RHESUS MACAQUES

H. A. Elfenbein1,2,3,4 and B. McCowan1,2,3,4
1One Shields Avenue, Davis, California 95616, USA, 2UC Davis School of Veterinary Medicine, 3California National Primate Research Center, 4Animal Behavior Graduate Group
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     Diarrhea is the leading cause of morbidity in captive non-human primates. In the most recent analyses, most of which are nearly 30 years old, each year up to 15% of animals in primate facilities develop diarrhea accounting for as much as 50% of hospitalizations and 31-44% of non-research related deaths. This clearly represents a significant health concern in addition to a severe economic burden due to such a high veterinary caseload. Given these figures, the epidemic of non-pathogenic diarrhea in primate facilities warrants investigation. We propose a retrospective analysis of factors in the animals’ life history that may increase risk. Diarrheal disease is a useful non-invasive outcome measure to understand an animal’s comprehensive physiological and psychological state, as declines in each are known risk factors for its development. Understanding which animals are at risk of developing diarrheal disease will potentially result in a reduction in incidence through modifications to colony management targeted at significant risk factors. Here, we identify the risk factors for the development of diarrhea through a retrospective epidemiological study of colony data. Hypothesized risk factors include age, sex, early life history including rearing, early environment, room relocations, social separation, and previous health history. Here we describe those factors significant for both indoor- and outdoor-housed animals as well as differences between acute cases and the chronic manifestation.