Abstract # 110:

Scheduled for Friday, June 22, 2012 02:10 PM-02:40 PM: Session 17 (Magnolia) Oral Presentation


CHALLENGES ASSOCIATED WITH DEVELOPING HUMANE ENDPOINT CRITERIA FOR NONHUMAN PRIMATES INVOLVED IN RESEARCH

K. R. Kelly
California National Primate Research Center, Primate Medicine Department, 1 Shields Avenue, Davis, CA 95616, USA
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     While most investigators and laboratory personnel recognize research on nonhuman primates (NHPs) cannot take place without protocol approval by an Institutional Animal Care and Use Committee (IACUC), few understand the challenges presented to veterinarians from submission to implementation of protocols. To properly address a unique scientific question, NHPs may experience direct or indirect pain and/or distress. Veterinarians must attempt to balance goals of investigators with needs of management and husbandry staff all while continuing to advocate for welfare of NHPs involved. Veterinarians are uniquely qualified for this task. They are well-educated in scientific methodology and well-trained in ethical advocacy for nonhuman beings. Development of clear endpoint criteria is crucial to supporting humane treatment of NHPs used in research, and veterinarians work with all parties to establish project-specific criteria. Humane endpoints help to establish objective criteria for minimizing pain and distress as well as helping to positively support scientific data collection. IACUC staff members enforce compliance of these developed criteria. Increased awareness of the many challenges associated with NHPs in research allows investigators to draft protocols appropriately addressing welfare concerns associated with their unique project(s). Many of these challenges will be identified followed by review of current literature on pain and distress in nonhuman primates. Quantification of humane endpoint criteria will be outlined and professional recommendations to address challenges discussed. Supported by NIH (T32-RR07038).