Abstract # 4316 Poster # 145:

Scheduled for Friday, June 22, 2012 07:00 PM-09:00 PM: Session 22 (Gardenia) Poster Presentation


R. H. Simon1,2, N. Maninger1,2, S. P. Mendoza1,2, B. J. Ragen1,2 and K. L. Bales1,2
1University of California, Davis, Department of Psychology, One Shields Ave., Davis, California 95616, USA, 2California National Primate Research Center
     Titi monkeys (Callicebus cupreus) are a monogamous primate that form lasting pair-bonds characterized by selective preference for the pair-mate, social buffering, and a physiological and behavioral response to separation. The purpose of this study was to examine how pharmacological activation of the serotonin 1A receptor would affect social behavior and peripheral hormones in the adult male titi monkey in an established pair bond. In a dose finding study, 4 subjects received each of 0.05, 0.1, 0.5 mg/kg 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT, a serotonin 1A receptor agonist) or saline vehicle subcutaneously. In the chronic-dosing study, 8 subjects were administered 0.1mg/kg 8-OH-DPAT or vehicle daily for 15 days. Blood samples were taken 15 and 45 minutes post injection on days 1, 3, 8, 10 and 15. Behavior was recorded for 30 minutes with the pair-mate and coded for locomotor, sexual, arousal and aggressive behavior. Blood plasma was assayed for oxytocin, vasopressin and cortisol. We hypothesized that acute 8-OH-DPAT would selectively increase, while chronic 8-OH-DPAT would decrease, affiliative behavior. Preliminary results indicate that unlike rats, a single dose of 8-OH-DPAT does not affect social behavior in the titi monkey, but does alter the cortisol response to handling and blood sampling (t= 3.27, p<.05). Funding: NIH HD053555, RR00169, and the Good Nature Institute