Abstract # 146:

Scheduled for Friday, June 22, 2012 07:00 PM-09:00 PM: Session 22 (Gardenia) Poster Presentation


DEVELOPMENT OF CORTICAL FOLDING AND GREY MATTER THICKNESS IN BONNET MACAQUES (MACACA RADIATA)

A. J. Bennett1, P. J. Pierre2, S. L. Bogart3 and W. D. Hopkins3,4
1Psychology Department, Harlow Center for Biological Psychology, University of Wisconsin-Madison, Madison, WI 53715, USA, 2Wisconsin National Primate Research Center, 3Yerkes National Primate Research Center, 4Agnes Scott College
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     Previous neuroimaging studies in nonhuman primates have reported many parallel patterns to human brain maturation, however they have focused on either overall or regional volumetric analysis. In the study reported here, we characterized age-related differences in specific aspects cortical organization in macaques, notably gyrification or cortical folding as well as grey matter (GM) thickness. Magnetic resonance images were obtained from 28 bonnet macaques ranging from 8 months to 10 years of age, 11 female and 17 male. Age comparisons of the mean depth and grey matter thickness of five sulci that are common to macaque, including the central, arcuate, rectus, sylvian fissure, and superior temporal, revealed several key findings. Like human infants, bonnet macaques show increased white relative to grey matter expansion during early development. Increased development of white matter was inversely linked to the development of cortical thickness. Population-level asymmetries in surface area, mean depth, or GM thickness, for any of the five sulci measured were not observed. Lastly, although no population-level biases were found, individual differences in asymmetries in grey matter thickness were inversely related to asymmetries in white but not grey matter. We believe the findings presented here are the first to report on the development of cortical folding and grey matter thickness in monkeys. Collectively, the findings suggest strong parallels between cortical development in monkeys and those patterns reported in humans.