Abstract # 106:

Scheduled for Friday, June 22, 2012 12:00 PM-12:15 PM: Session 16 (3rd Floor All Space) Oral Presentation


EVIDENCE OF INFLUENZA VIRUS INFECTION IN PRIMATES AT THE HUMAN-ANIMAL INTERFACE

G. Engel1,2, E. A. Karlsson3, M. Feeroz4, S. San5, A. Rompis6, B. P. Lee7, E. Shaw8, G. Oh1, S. Schultz-Cherry3 and L. Jones-Engel1
1WANPRC, University of Washington, Seattle, WA 98195, USA, 2Swedish Cherry Hill, Family Medicine, Seattle, WA, 3St Jude Children’s Research Hospital, Memphis, TN, USA, 4Department of Zoology, Jahangirnagar University, Savar, Bangladesh, 5National Veterinary Research Institute, Phnom Penh, Cambodia, 6Universitas Udayana, Bali, Indonesia, 7Nature Parks, Parks Division, National Parks Board, Singapore, 8Gibraltar Ornithological and Natural History Society, Gibraltar
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     Influenza viruses are well known pathogens of humans, with both epidemic and seasonal infection exacting a substantial toll in terms of global morbidity and mortality. Research in laboratory settings shows that nonhuman primates (NHP) are susceptible to influenza, but little is known about the prevalence of influenza infection in NHP in natural settings. We measured the seroprevalence of antibodies to seasonal and avian influenza virus in synanthropic NHP (those capable of thriving alongside humans in human-altered environments) in order to determine whether NHP with high human contact become infected with influenza. Sera were collected between 2001 and 2011 from a total of 236 animals in Singapore, Bangladesh, Gibraltar, Cambodia and two sites in Indonesia and analyzed for the presence of neutralizing antibodies to specific stains of influenza virus circulating in each region at or prior to time of sampling. 14 sera contained antibodies to influenza virus; neutralizing antibodies against seasonal H1N1 and H3N2 strains and avian H9N2 strains were detected. No antibodies to highly pathogenic H5 viruses were found. These results demonstrate that synanthropic macaques are susceptible to both seasonal and avian influenza virus infections and suggest further research to determine the role NHP may play in influenza ecology.