Abstract # 133:

Scheduled for Friday, June 22, 2012 07:00 PM-09:00 PM: Session 22 (Gardenia) Poster Presentation


THE VERVET RESEARCH COLONY AS A BIOMEDICAL RESOURCE

M. J. Jorgensen1, L. L. Rudel1, K. Kavanagh1, A. J. Jasinska2, N. B. Freimer2, J. D. Jentsch2, L. A. Fairbanks2, M. T. Fallon3 and J. R. Kaplan1
1Wake Forest School of Medicine, Department of Pathology/Comparative Medicine, Medical Center Blvd., Winston-Salem, NC 27157-1040, USA, 2University of California, Los Angeles, 3Atlanta VA Medical Center
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     The Vervet Research Colony (VRC) is a multi-generational, pedigreed and genotyped colony of Caribbean-origin vervets/African green monkeys (Chlorocebus aethiops sabaeus), originally founded in 1975. The current population contains 450 US-born animals (0-26 years old) descended from 57 founders. The VRC is funded by NIH and the VA to maintain a pathogen-defined pedigree, enabling NIH-supported researchers to engage in longitudinal or short-term phenotypic investigations using the pedigree under controlled environmental and genetic conditions, and to conduct linkage and association studies in relation to a wide range of biomedically relevant traits. Animals are available for purchase or on-site utilization. An extensive data, sample and tissue repository is also available. Data include demographic, weight, morphometric, lipid, cardiometabolic, CBC, blood chemistry, vitamin D, hair cortisol, whole body CT, brain MRI, and behavioral measures. Archived samples include plasma, serum, DNA, RNA, and fibroblastic cultures. Tissue archives include fixed and frozen samples from over 20 different organs from experimental and diagnostic necropsies. Genomic resources include pedigree, genotype, transcriptome, and microbiome data. In addition, whole genome sequencing of 723 individuals from animals with associated phenotypic data and/or tissue samples is currently underway. Recent publications from the VRC include studies of diet, environmental stress and/or genetic influences on diabetes, brain morphology, stress reactivity, early development, aging and behavioral traits related to vulnerability for psychopathology. Supported by NIH grant (RR019963/OD010965), WFSM, UCLA and DVA.