Abstract # 4409 Event # 199:

Scheduled for Saturday, June 22, 2013 10:15 AM-10:30 AM: Session 24 (Auditorium) Oral Presentation


NEUROBIOLOGY OF PAIR-BONDING IN MONOGAMOUS TITI MONKEYS

K. L. Bales1,2, K. Hinde2,3, N. Maninger2, W. A. Mason2 and S. P. Mendoza2
1University of California, Department of Psychology, Davis, CA 95616, USA, 2California National Primate Research Center, 3Department of Human Evolutionary Biology, Harvard University
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     Titi monkeys represent an ideal non-human primate model for the neurobiology of pair-bonding. They form strong pair-bonds, characterized by selective preference for their partner, mate-guarding, physiological and behavioral agitation upon separation, and social buffering. In a series of studies, we measured the neural effects of pair-bond formation, longitudinal changes in the pair-bond, and pair-bond challenges such as separation or "jealousy" in coppery titi monkeys (Callicebus cupreus) housed at the California National Primate Research Center. In these studies, conducted via positron emission tomography (PET) co-registered with MRI, we found a number of similarities and differences between the neurobiology of pair-bonding in titi monkeys and published studies in rodents and humans. Particularly interesting is the significant (F= 3.60,n = 12, p = 0.026) increase in whole brain glucose uptake which occurs across the process of pair-bond formation and consolidation, as well as significant changes in the lateral septum (F = 10.94,n = 16, p = 0.016) in a "jealousy" condition which parallels similar findings in human obsessive love. The natural social characteristics of titi monkeys make them useful models for both basic and biomedical research on social bonds. This research is supported by HD053555, US National Institutes of Health Office of Research Infrastructure Programs, grant P51OD011107; and the Good Nature Institute.